脂质积累产品与慢性阻塞性肺病之间的关联:基于美国成年人的横截面研究
Xingshi Hua1,2, Ying Liu1,3, Xiaoyu Xiao1
1Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Frontiers in nutrition
|January 27, 2025
概括
较高的脂质积累产品 (LAP) 水平与慢性阻塞性肺病 (COPD) 风险增加有关. 这种关联显示出非线性模式,表明LAP可能有助于早期COPD风险评估.
科学领域:
- 心血管健康 心血管健康
- 呼吸系统医学 呼吸系统医学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 脂质积累产品 (LAP) 是一种脂质积累的标志物,来自腰围和甘油三水平.
- 功能障碍性脂质积累越来越多地与慢性阻塞性肺病 (COPD) 的病原发生有关.
- 关于LAP和COPD风险之间的关联的研究,特别是在以人口为基础的研究中,仍然有限.
研究的目的:
- 调查LAP与患COPD的风险之间的潜在相关性.
- 检查LAP和COPD之间的非线性关系.
- 评估这种关联在不同的人口分组中的一致性.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2017-2020年) 进行横截面分析,共有7113名参与者.
- 从腰围和甘油三水平计算的脂质积累产物 (LAP);COPD通过自我报告来诊断.
- 多变量逻辑回归和平滑曲线适合分析LAP-COPD关联,对性别,吸烟和酒精摄入量进行子组分析.
主要成果:
- 在ln LAP和COPD风险之间发现了显著的积极关联 (OR=1.16,95% CI:1.04-1.30).
- 在 ln LAP 的最高四分位数中,与最低四分位数 (OR=1.35,95% CI:1.04-1.75) 相比,患上 COPD 的可能性要大得多.
- 调整曲线的拟合显示了 ln LAP 和 COPD 风险之间的非线性,正相关性,风险在较高的 LAP 水平上升得更快.
结论:
- 升高的LAP水平与COPD风险增加显著相关.
- 观察到的非线性关联凸显了LAP作为COPD风险评估的有价值生物标志物的潜力.
- LAP可能有助于早期识别和针对性管理策略,针对COPD风险的个体.
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