漫游神经刺激在胃肠道疾病中的有效性:系统性审查
Fleur Veldman1, Kimberly Hawinkels1, Daniel Keszthelyi1
1Department of Gastroenterology-Hepatology, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.
Gastroenterology report
|January 27, 2025
概括
非侵入性迷走神经刺激 (VNS) 通过改善症状,显示出治疗胃肠道疾病的前景. 这种疗法是安全的,副作用很少,但需要进一步的研究以更广泛地应用.
科学领域:
- 胃肠病学和神经病学
- 神经胃肠病学 神经胃肠病学
- 治疗神经调节治疗神经调节
背景情况:
- 迷走神经功能障碍与各种胃肠道 (GI) 疾病有关.
- 迷走神经刺激 (VNS) 是作为一种非药物治疗选择被探索的.
- 系统性审查,以评估VNS在GI条件下的有效性.
研究的目的:
- 系统地审查侵袭性和非侵袭性VNS对肠道疾病的疗效.
- 在包括IBD,IBS,FD和胃衰竭在内的条件下评估VNS.
- 与假刺激相比,评估VNS的症状缓解和安全性.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane图书馆进行系统的文献搜索.
- 包含随机对照试验 (RCT),将VNS与假控制进行比较.
- 使用修订后的Cochrane偏差风险工具对方法质量的评估.
主要成果:
- 七项涉及644名患者的RCT集中在FD,IBD,IBS和功能性腹痛的非侵入性VNS上.
- 与假药相比,非侵入性VNS在患者子组中显著改善了症状.
- 报告的不良事件是最小的,没有观察到严重并发症.
结论:
- 非侵入性VNS显示出作为各种胃肠道疾病的安全有效治疗的潜力.
- 假定机制涉及抗炎和抗nociceptive效应.
- 由于样本规模较小和初步发现,需要进一步研究.
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