在心血管疾病中,能量代谢和NADPH氧化酶介导的病理生理学之间的相互作用
Haipeng Jie1, Jingjing Zhang1, Shuzhen Wu1
1Department of Cardiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Frontiers in pharmacology
|January 27, 2025
概括
活性氧物种 (ROS) 的氧化应激和能量代谢受损导致心血管疾病 (CVD),特别是代谢障碍. 向NADPH氧化酶 (NOX) 可能提供新的治疗策略.
科学领域:
- 生物化学 生物化学
- 心血管研究研究心血管研究
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 反应性氧物种 (ROS) 和抗氧化剂不平衡与心血管疾病 (CVD) 有关,这些疾病由糖尿病和高胆固醇血症等代谢条件加剧.
- NADPH氧化酶 (NOX) 是ROS的关键来源,在纤维化和缩等生理和病理心血管过程中影响氧化还原信号.
- 线粒体在压力下增加蛋白质和能量生产,与超氧化激素的升高相关,突出了病态状态中的作用.
研究的目的:
- 审查在心血管疾病中氧化应激和能量代谢之间的相互作用,特别是在代谢障碍的背景下.
- 阐明在有代谢障碍的个体中心血管疾病发病率增加的基础机制.
- 探索NOX,能量代谢和心血管疾病中的铁亡之间的关系.
主要方法:
- 文献综述整合了关于心血管疾病中氧化应激,能量代谢和NOX的最新数据.
- 分析NOX介导的调节机制,用于在病理条件下维持能量平衡.
- 关于NOX,能量代谢和铁亡之间的相关性的初步讨论.
主要成果:
- 持续的ROS生产和不平衡的抗氧化剂系统与心血管疾病的发展有关,特别是代谢障碍.
- 氧化酶是ROS的重要贡献者,在心血管病理生理学中调解氧化还原信号.
- 在病理性压力下,NOX4在调节能量代谢恒温中发挥着至关重要的作用.
结论:
- 了解氧化应激和能量代谢之间的相互作用对于解释代谢障碍中心血管疾病发生率至关重要.
- 对NOX和能量代谢交叉的进一步研究,包括铁亡,可能会导致新的治疗点.
- 准NOX路径为开发有效的CVD管理策略提供了潜力.
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