长期的语言下细菌免疫疗法可以预防耳鼻喉感染:一项实践研究
Paula F Aarestrup1, Matheus F Aarestrup2, Beatriz Jv Aarestrup3
1Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo, São Paulo, Brazil.
SAGE open medicine
|January 27, 2025
概括
语言下细菌免疫疗法在预防耳鼻喉感染方面显示出显著的潜力. 这种治疗是安全有效的,即使在停止治疗后也能提供持久的保护.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 细菌提取物在预防呼吸道感染方面有着悠久的历史.
- 最近的研究强调了通过免疫记忆"训练免疫力"的潜力.
- 本研究重点是针对耳鼻喉 (ENT) 感染的语言下细菌免疫疗法 (SBT).
研究的目的:
- 为了研究细菌免疫疗法在预防耳鼻喉感染的疗效.
- 评估长期语言下细菌免疫疗法的安全性.
- 为了评估治疗完成后保护作用的持续时间.
主要方法:
- 一项观察性研究涉及患者接受12个月的语言下细菌免疫疗法.
- 记录了基线ENT感染史,并在6,12,18和24个月后进行随访.
- 在整个24个月的随访期间,对不良事件进行了监测.
主要成果:
- 观察到,耳,耳,耳,耳,耳,耳感染发作显著减少:75.68%在6个月,82.27%在12个月,82.78%在18个月,89.88%在24个月.
- 没有报告与语言下细菌免疫疗法管理相关的不良反应.
- 预防性益处在整个24个月的随访期间持续存在.
结论:
- 长期的舌下细菌免疫疗法是预防耳鼻喉感染的安全有效策略.
- 该疗法对减少感染频率产生持续的积极影响.
- 免疫效益似乎延伸到活跃治疗阶段之外,这表明持久的保护.
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