婴儿呼吸道感染调节淋巴细胞向母乳转移
Yingying Zheng1, Simone Corrêa-Silva2, Regina Maria Rodrigues1
1Department of Pediatrics, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Frontiers in immunology
|January 27, 2025
概括
婴儿呼吸道感染会增加母乳中的免疫细胞和信号分子. 这种反应增强了被动免疫力,并支持婴儿免疫系统的发展.
科学领域:
- 免疫学 免疫学 免疫学
- 人类牛奶中的寡糖化物
- 新生儿健康 新生儿健康
背景情况:
- 化基因及其受体对于引导白细胞迁移到包括母乳在内的各种组织至关重要.
- 了解淋巴细胞向母乳转移的理解对于理解从母亲到婴儿的被动免疫转移至关重要.
研究的目的:
- 调查T和B淋巴细胞子集在婴儿呼吸道感染期间对母乳的定位.
- 分析牛奶淋巴细胞上的指导受体 (CCR5,CCR6,CCR10,CXCR3) 的表达.
- 量化母乳血清和母乳中的化学激素,细胞激素和抗体水平.
主要方法:
- 从患有 (I组) 和没有 (C组) 呼吸道感染的婴儿的母亲那里收集血液和成熟的牛奶.
- 在牛奶中量化淋巴细胞子集和指导受体表达.
- 在母体血清和牛奶中测量了化学激素,细胞激素和IgA/IgG抗体水平.
主要成果:
- 与对照组 (C组) 相比,在患有感染婴儿的母亲的牛奶中 (I组) 观察到总淋巴细胞,T细胞和B细胞数量显著增加.
- 在CD4 T细胞中发现了CCR5,CCR6和CXCR3的高表达,在I组牛奶中发现了CD8 T细胞中的CCR6和CXCR3.
- 在I组牛奶中,发现了CCR6+B细胞子集,CXCR3+原始B细胞和血细胞的数量增加,牛奶中CCL20,CXCL10,IL-6,IL-8,IgA和IgG的含量更高.
结论:
- 哺乳期婴儿的呼吸道感染引发母乳中细胞因子和化学因子的增加,促进淋巴细胞的招募和激活.
- 这种牛奶免疫反应可能有助于免疫耐受性和婴儿免疫系统成熟.
- 这些发现表明,通过母乳的免疫成分调解的被动母婴保护的额外机制.
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