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在年轻的印度成年人中发生的转氨酸炎和与代谢功能障碍相关的胆固醇性肝病的患病率 - 一项基于人口的研究
Abilash Nair1, Jabbar Puthiyaveettil Khadar1, Archana Mohan Preetha1
1Department of Endocrinology and Metabolism, Govt. Medical College, Thiruvananthapuram, India.
Journal of clinical and experimental hepatology
|January 27, 2025
概括
年轻的印度成年人患有代谢功能障碍相关的脂肪性肝病 (MASLD) 和转氨炎的高患病率. 在这个人群中,建议对MASLD和横炎进行早期查.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 青年的代谢功能障碍相关的脂肪性肝病 (MASLD) 可能导致比成人更糟糕的结果.
- 膜炎是MASLD患病率的一个指标.
- 之前没有任何基于社区的研究评估过印度年轻人中肌膜炎的患病率.
研究的目的:
- 为了确定肌膜炎的流行率.
- 为了评估MASLD的流行率.
- 评估南印度年轻成年人中纤维化-4 (FIB-4) 指数升高的患病率.
主要方法:
- 一项跨界研究进行了一年 (从2022年1月开始),包括2373名年龄在18-30岁之间的成年人.
- 多阶段采样从四个地区招募了BMI<30 kg/m2且没有大量饮酒的参与者.
- 收集的数据包括病史,体检,肝酶 (ALT,AST),血小板计数,代谢标志物,FIB-4指数和非酒精性脂肪肝疾病-肝脏脂肪评分 (NAFLD-LFS).
主要成果:
- 在25.9%的参与者中观察到过敏素炎 (AST或ALT≥35IU/L).
- 由NAFLD-LFS (≥-0.64) 识别的MASLD存在于27.4%的人口中.
- 在2.27%的参与者中发现FIB-4指数升高 (≥1.3). 子周长和Trivandrum医学院脂肪指数与肌炎,MASLD和高FIB-4相关.
结论:
- 在年轻的,社区居住的印度成年人中存在显著的透视膜炎和MASLD的流行率.
- 建议对所有年轻的印度成年人进行MASLD和膜炎的查.
- 对这一人口群体的特定风险因素和长期影响进行进一步的研究是有必要的.
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