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经常出现的致癌ZC3H18突变稳定了内源性逆转录病毒RNA

Tanzina Tanu1, Anna M Cox1, Jennifer Karlow2

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

bioRxiv : the preprint server for biology
|January 27, 2025
PubMed
概括

ZC3H18 (Z18) 中的突变通过破坏核RNA监测来促进癌症,导致内源性逆转录病毒 (ERV) RNA积累增加. 这种ERVRNA积累加速了癌症的发展,突出了一个新的致癌机制.

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