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Updated: May 30, 2025

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
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Published on: May 13, 2020

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APE1活性部位残留物Asn174稳定了AP部位,对于催化是必不可少的

Kaitlin M DeHart, Nicole M Hoitsma, Spencer H Thompson

    bioRxiv : the preprint server for biology
    |January 27, 2025
    PubMed
    概括

    阿普里尼克/阿普里米迪尼克 (AP) 位点内核酶1 (APE1) 残留物N174对于DNA修复至关重要. 破坏其与AP位点相互作用的突变阻碍了催化,揭示了N1744.

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