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Updated: May 30, 2025

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
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Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

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PAX3-FOXO1驱动了可向细胞状态依赖的代谢脆弱性在拉布多米索尔科马

Katrina I Paras, Julia S Brunner, Jacob A Boyer

    bioRxiv : the preprint server for biology
    |January 27, 2025
    PubMed
    概括

    PAX3-FOXO1通过改变皮里米丁代谢来驱动侵略性狂宫肌肉瘤. 使用甲基酸盐抑制二叶酸减少酶 (DHFR) 有效地向这些癌细胞,为儿科瘤提供了一种新的治疗策略.

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    Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas09:21

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    Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

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