结构机制用于识别E2F1由ubiquitin结合酶适配器Cyclin F识别E2F1

Peter Ngoi1, Xianxi Wang2, Sivasankar Putta1

  • 1Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA.

概括

环素F是一种独特的细胞循环调节剂,在E3无素酶复合体中充当基质受体. 与Cyclin A相比,结构分析揭示了与Cyclin A相比不同的E2F1结合机制,进步了对细胞循环控制的理解.

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