抑郁症尺寸与社区老年人认知功能之间的关联:90后的生活研究
Laili Soleimani1, Andrew Hirst2, Paola Gilsanz2
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
概括
在老年人中,主观记忆问题和绝望与认知能力下降有关. 这些抑郁症维度可以识别高风险个体,以便进行早期干预.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 最老的老年人 (90岁以上) 是增长最快的人口群体,面临着最高的痴呆风险.
- 抑郁症是认知能力下降的常见风险因素,但其表现是异质的.
- 了解特定的抑郁症维度对这一群体认知的影响至关重要.
研究的目的:
- 探索90岁及以上成年人的不同抑郁症维度和认知功能之间的关联.
- 检查随着时间的推移与基线抑郁症维度相关的认知变化.
主要方法:
- 利用了来自种族/种族多样化的LifeAfter90研究队列 (n=960) 的数据.
- 通过测量情节性记忆,语义记忆和执行功能来评估认知.
- 使用老年抑郁症尺度-15项 (GDS-15) 测量了基线抑郁症,确定了主观记忆抱怨 (SMC) 和绝望等维度.
- 采用了通用线性混合模型来分析抑郁症维度和认知结果之间的关联,并根据人口统计因素进行调整.
主要成果:
- 主观记忆投诉 (SMC) 与较差的全球认知,执行功能和口头情节性记忆显著相关.
- 绝望与更糟糕的执行功能有关.
- 基线绝望表明,在1.2年内,情节性记忆的下降趋势更快.
结论:
- 特定的抑郁症维度,特别是主观记忆投诉 (SMC) 和绝望,与老年人的认知障碍和衰退有关.
- 这些发现表明,识别这些抑郁症维度可以帮助确定这个脆弱人群中患有认知衰退高风险的个人.
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