粉补充剂可以增强小鼠的免疫功能,部分是通过调节肠道微生物群和氨酸代谢
Jinhui Jia1,2, Jian Guo1,2, Chunhong Yan1,2
1State Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian, Liaoning 116034, China. foodscixiaodong@dlpu.edu.cn.
Food & function
|January 27, 2025
概括
吃可以通过改善肠道健康和增加L-氨酸水平来提高免疫功能. 这种饮食策略显示出增强免疫力和抵消免疫抑制的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物组研究的研究.
- 营养科学 营养科学
背景情况:
- 鱼具有已知的免疫调节特性.
- 肠道微生物组在调节饮食对免疫调节的影响方面发挥着至关重要的作用.
- 环胺 (Cy) 是一种诱导免疫抑制的化疗剂.
研究的目的:
- 调查食是否可以减轻Cy诱导的免疫抑制.
- 探索对肠道平衡和免疫参数的影响.
- 阐明潜在的免疫调节作用背后的机制.
主要方法:
- 小鼠接受了循环胺 (Cy) 治疗,以诱导免疫抑制.
- 用粉给 Cy 治疗的小鼠的一小组.
- 分析了免疫细胞数量,血清细胞因子水平,肠道微生物群组成和代谢量.
主要成果:
- 补充剂抵消了Cy诱导的和小肠免疫细胞的减少.
- 主要免疫细胞因子 (IL-1β,IL-2,TNF-α,IFN-γ) 的血清水平因食用而增加.
- 的摄入量调节了肠道微生物群,有利于有益的细菌,并提高了阿尔金因生物合成途径的调节,增加了L-阿尔金因水平.
结论:
- 饮食中食用可以增强免疫反应,促进肠道平衡.
- 可能通过调节肠道微生物群和促进氨酸生物合成来支持免疫力.
- 吃是一种有前途的饮食方法来支持免疫健康.
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