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在Staphylococcus pseudintermedius分离物上 Lactobacillus casei 的抗菌活性
Danielle Cavalcanti de Carvalho Diniz1, Marcio Garcia Ribeiro1, Gabriele Silva Dias1
1Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, Brazil.
Veterinary dermatology
|January 27, 2025
概括
一种狗皮肤细菌,Lactobacillus casei,有效地抑制了常见的皮肤湿疹的常见原因,伪中间体葡萄球菌. 这种益生菌为治疗犬类细菌性皮肤感染提供了抗生素的潜在替代品.
科学领域:
- 兽医皮肤病学 兽医皮肤病学
- 微生物学 微生物学
- 益生菌 益生菌 益生菌
背景情况:
- 抗菌素耐药性是一个日益严重的全球健康问题,导致死亡率增加和治疗选择减少.
- 新抗微生物药物的发展缓慢,需要探索替代疗法.
研究的目的:
- 从健康的狗中分离和识别一个Lactobacillus casei菌株.
- 为了评估这种L. casei菌株对从患有皮肤病的狗中分离的Staphylococcus pseudintermedius菌株的抗菌疗效.
主要方法:
- 乳杆菌casei从狗皮肤中分离出来,并使用MALDI-TOFMS识别.
- 对30个临床分离物和一个参考菌株的抗微生物活性进行了评估,这些菌株是 Staphylococcus pseudintermedius 使用点在草技术.
- 安全性通过修改的Kirby-Bauer磁盘扩散试验来评估.
主要成果:
- 乳杆菌casei证明了对所有测试的Staphylococcus pseudintermedius分离物的抑制作用,平均抑制光环为11.3毫米.
- 在L. casei产生的抑制光环和标准抗菌素盘之间观察到显著的正相关性.
- L. casei菌株对所有测试的抗微生物药物都敏感,这表明其安全性概况有利.
结论:
- 共生细菌,如来自狗皮的Lactobacillus casei,显示出作为细菌感染的补充或替代疗法的希望.
- 这种方法可能与管理狗狗的Staphylococcus pseudintermedius感染有关,可能减少对抗生素的依赖.
- 进一步研究从动物共生物中获得的益生菌疗法可能会使兽医和人类医学受益.
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