结直肠癌治疗后的慢性疼痛:基于人口的横截面研究
Hossam Elfeki1,2, Reem A Alharbi3,4, Therese Juul5,6,7
1Department of Surgery, Mansoura University Hospital, Mansoura, Egypt.
概括
慢性疼痛影响了超过40%的结直肠癌幸存者,15%的人经历了严重的疼痛. 年轻的患者,女性和接受特定治疗的人面临更高的风险,需要知情同意和有针对性的支持.
科学领域:
- 在瘤学瘤学.
- 疼痛医学 医学 疼痛医学
- 手术结果研究研究.
背景情况:
- 慢性疼痛是结肠直肠癌治疗后的一个显著的长期并发症.
- 现在可以使用验证的工具来准确评估术后的慢性疼痛.
研究的目的:
- 为了确定结直肠癌治疗后慢性疼痛的患病率.
- 确定与发展慢性疼痛相关的人口和治疗相关的风险因素.
主要方法:
- 一项全国横截面问卷研究分析了2001年至2014年期间接受治疗的11600名结直肠癌患者的数据.
- 多变量逻辑回归确定了慢性疼痛的预测因素,报告了几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 总体疼痛患病率为41.5%,其中15.4%的人经历了严重的疼痛.
- 重度疼痛在直肠癌患者中更为常见.
- 严重疼痛的关键预测因素包括年轻年龄 (<60岁),女性性别,开放性手术,化疗,放射治疗,永久性静脉口腔,并发症和静脉口腔泄漏.
结论:
- 慢性疼痛是结肠直肠癌幸存者的一个非常普遍的问题.
- 在开始治疗之前,应确定患有严重疼痛风险增加的患者,并向他们告知潜在风险.
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