在睡眠行走者中,功能连接和代谢性大脑变化发生
Greta Mainieri1,2, Magali Jane Rochat3, Elena Cantoni3
1Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
兴奋障碍 (DoA) 患者在感官运动网络中显示出大脑连接的改变,并在后带带皮层中减少了谷氨酸. 这些变化可能解释了DOA的兴奋功能障碍和白天障碍.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 神经成像是一种神经成像.
背景情况:
- 兴奋障碍 (DoA) 涉及不完全从睡眠中唤醒,即使在清醒时也观察到微妙的神经生理变化.
- 后带带皮质 (PCC) 对于认知和情绪处理至关重要,因此它是DoA研究的关键领域.
研究的目的:
- 在DoA患者中调查大脑功能连接和前后环状皮质的代谢概况.
- 探索DoA中兴奋功能障碍和相关症状的潜在神经生物学基础.
主要方法:
- 采用多模式脑MRI,包括静止状态功能MRI (rs-fMRI) 和1H-MR光谱.
- 使用独立组件分析和基于种子的分析分析了功能连接 (FC).
- 评估了15名DoA患者和15名年龄/性别匹配的健康对照,包括睡眠和心理评估.
主要成果:
- DoA患者在感官运动网络中表现出改变的静止状态功能连接 (FC),在特定的皮层和尾区域的连接性增加.
- 在DoA患者的后带皮质 (PCC) 和其他大脑区域之间观察到CF的减少.
- 与对照组相比,光谱成像显示DoA患者PCC中的谷氨胺水平显著降低.
结论:
- 在DoA中增加的感觉电机网络连接可能会促进电机电路的激活.
- 在DoA中改变的PCC连接和新陈代谢可能是导致兴奋功能障碍和意识受损的特征特征.
- 这些静止状态的变化可能与白天的损伤相关,这表明需要DoA的新型管理策略.
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