三十年来,夏威夷的肝癌病原发生变化
Linda L Wong1,2, Larry R Hromalik1, Brenda Y Hernandez2
1Department of Surgery, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii.
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越多地与夏威夷的肝癌 (HCC) 相关,反映了国家趋势. 对代谢风险因素的管理对于减少HCC的负担至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 全球肝硬化病的增加,有助于肝细胞癌 (HCC).
- 与大多数美国地区相比,夏威夷的HCC发病率更高.
- 需要调查夏威夷的HCC病因局部趋势.
研究的目的:
- 评估三十年来夏威夷HCC人口统计和病因学的变化.
- 确定夏威夷是否反映了与肝硬化相关的HCC增加的全球趋势.
- 为了评估代谢风险因素对夏威夷HCC的影响.
主要方法:
- 对1991年至2023年间诊断的1651例高血糖瘤病例进行了回顾性分析.
- 在研究期间,包括夏威夷所有HCC病例的60-70%.
- 评估患者人口统计,风险因素和疾病原因的时间趋势.
主要成果:
- 从1991年到2023年,与代谢功能障碍相关的脂肪性肝病 (MASLD) 相关的HCC病例显著增加.
- 与HCC相关的代谢风险因素 (肥胖,糖尿病,高脂血症,高血压) 的患病率增加.
- 单独患有肝硬化的HCC病例比例下降;C型肝炎病毒 (HCV) 和B型肝炎病毒 (HBV) 相关的HCC的趋势波动.
- 到2020年,有吸烟史的HCC病例增加;酒精相关病例的比例稳定.
结论:
- 虽然HBV仍然是夏威夷的重要HCC贡献者,但MASLD和代谢风险因素越来越普遍.
- 夏威夷的HCC趋势与国家模式一致,强调了代谢功能障碍日益增长的作用.
- 对代谢因素的有针对性管理对于减轻夏威夷日益增加的HCC负担至关重要.
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