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感官症状作为活跃白风的早期表现:一个病例对照临床和分子研究
Hagar El Sayed1, Hala El Wakeel1, Zeinab Nour2
1Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt.
Pigment cell & melanoma research
|January 27, 2025
概括
在白风患者,特别是活跃病例中,像这样的感觉症状可能会先于皮肤病变. 神经Y (NPY),素基因相关 (CGRP) 和神经生长因子 (NGF) 在活跃的白皮肤中较低.
科学领域:
- 皮肤病学 皮肤病学
- 神经免疫学 神经免疫学
- 皮肤感官科学 皮肤感官科学
背景情况:
- Vitiligo 的发病过程是复杂的,新出现的证据表明神经激素通路的参与.
- 虽然经常被认为是无的,但一些白风患者报告感觉症状,包括,在病变出现之前.
研究的目的:
- 为了研究活跃和稳定的白风患者的感觉症状.
- 在受伤皮肤中量化神经Y (NPY),素基因相关 (CGRP) 和神经生长因子 (NGF).
- 为了将神经水平和感官症状与白风疾病活动相关联.
主要方法:
- 一项病例控制研究,涉及85名成年白风患者 (活跃或稳定) 和一个健康的对照组.
- 对感觉症状 (,麻醉,麻木) 的查和使用验证得分 (白风疾病活动得分,白风活动迹象得分,皮肤镜得分) 评估疾病活动.
- 从白病变边缘的皮肤活检中通过酶相关的免疫吸收试验量化NGF,CGRP和NPY.
主要成果:
- 24.7%的患者报告了感官症状: (18.8%),麻醉 (2.4%),麻木 (3.5%).
- 与稳定和活跃白病患者相比,在正常对照组中观察到显著更高的NGF,CGRP和NPY水平.
- 神经水平在活跃的白病皮肤中最低,NGF与疾病活动和感官表现有最强的相关性.
结论:
- 感官表现,特别是,被大量活跃白风患者报告,可能表明疾病活动的前期阶段.
- 活跃白病皮肤中NGF,CGRP和NPY水平的降低表明这些神经在疾病过程中发挥了作用.
- 感官症状查可以作为评估白风活动的宝贵工具.
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