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循环基细胞计数与胃癌预后的关联

Makiko Kawano¹, Yoko Oshima², Fumiaki Shiratori¹

¹Department of Gastroenterological Surgery, Toho University Medical Center Omori Hospital, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 142-8541, Japan.

Journal of gastrointestinal cancer

|January 27, 2025

概括

胃癌患者的低基细胞计数表明预后较差. 这一发现表明,在手术前评估基细胞水平可以帮助预测患者的生存结果.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

基细胞是过敏反应和寄生虫感染的关键参与者.
低基细胞计数已成为各种癌症中潜在的负预后标志物.

研究的目的:

在胃癌患者中确定基细胞计数的预后意义.
为了确定确定低基细胞计数的截止值.

主要方法:

分析了1192名经过手术的胃癌患者的数据.
使用接收器运行特征曲线以建立26/μl的基细胞计数切线.
使用单变量和多变量分析评估临床病理学和预后意义.

主要成果:

低基细胞计数 (<26/μl) 与老年,高C反应蛋白和较低的淋巴细胞/中性细胞计数有关.
基细胞数量较低的患者的整体存活率明显降低 (p=0.005).
低基细胞计数是胃癌总生存率差的一个独立风险因素 (HR=1.29,p=0.027).

结论:

低基细胞计数与特定的临床因素有关,并作为胃癌预后不佳的独立预测因子.
在手术前评估循环亚基细胞数量可能有助于预测术后存活率.

关键词:

基细胞的数量胃癌是什么?胃癌是什么?预测预后预测预测

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