肠道微生物与慢性乙型肝炎的功能治愈有关
Takashi Honda1, Masatoshi Ishigami2, Yoji Ishizu2
1Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan. honda@med.nagoya-u.ac.jp.
Hepatology international
|January 27, 2025
概括
产生酸盐的肠道细菌,特别是产生酸盐的肠道细菌,与慢性乙型肝炎病毒 (HBV) 患者的功能治愈有关. 这些细菌可能会抑制HBV的产生,有助于实现功能治愈.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 微生物组研究 微生物组研究
- 病毒学 病毒学
背景情况:
- 慢性乙型肝炎病毒 (HBV) 感染是一个全球性健康挑战,治疗选择有限.
- 实现功能治愈 (FC) 是当前HBV治疗的主要目标,但影响FC的因素尚未完全理解.
- 研究肠道微生物群在HBV FC中的作用对于开发新型治疗策略至关重要.
研究的目的:
- 探索慢性乙型肝炎患者的肠道微生物群概况,这些患者已经实现了功能治愈 (FC).
- 为了确定与HBeAg阴性慢性HBV患者中与FC相关的特定细菌物种或功能.
- 评估由肠道细菌产生的短链脂肪酸 (SCFA) 在体外对HBV感染的影响.
主要方法:
- 在70名HBeAg阴性慢性HBV患者的肠道微生物组合分析,根据FC状态,高HBVDNA标位或低HBVDNA标位分类.
- 患者组之间的微生物多样性 (α和β) 的比较.
- 使用细胞培养产生的HBV (HBVcc) 进行体外研究,以评估SCFA,特别是酸盐对HBV产生的影响.
主要成果:
- 在FC组与其他患者组之间没有观察到肠道微生物群α或β多样性的显著差异.
- FC组表现出较高的SCFA产生细菌的相对丰度,特别是那些生产丁酸盐的细菌.
- 在体外,丁酸盐 (1.0mM) 有效地降低了HBsAg在HBVcc感染细胞中的产生,在感染后的阶段具有最佳的疗效.
结论:
- 这项研究表明,肠道微生物群中大量产生酸盐的细菌与HBeAg阴性慢性HBV患者的功能治愈有关.
- 这些细菌产生的丁酸盐似乎通过抑制HBV的产生,有助于功能治愈.
- 向酸盐生产细菌或酸盐补充剂可能代表了一种新的治疗方法,以实现慢性乙型肝炎的功能治疗.
相关概念视频
01:17Chronic Bowel Disorders: Introduction
385
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
385
01:23Anatomy of the Intestines
71.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K
01:29Bacterial Flora of the Large Intestine
376
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
376
01:50What is Monogastric Digestion?
70.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.5K