Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Nucleic Acid Structure01:25

Nucleic Acid Structure

5.9K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
5.9K
Phosphodiester Linkages01:01

Phosphodiester Linkages

98.6K
Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
98.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Uninterrupted optical resolution of identical point scatterers undergoing nanometric changes in distance.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

DNA origami snaps into place.

Science robotics·2026
Same author

Volume and surface methods for microparticle traction force microscopy: a computational and experimental comparison.

Soft matter·2026
Same author

Mechanically Programmable DNA Hydrogel Microparticles for 3D Cellular Systems.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Membrane-Spanning Nanopores Formed from Nucleic Acids.

Chemical reviews·2026
Same author

Two-dimensional HRS condensates drive the assembly of flat clathrin lattices on endosomes.

Nature communications·2026

相关实验视频

Updated: May 30, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.5K

折叠和功能化DNA原形:一种使用反应性聚胺的多功能方法

Alejandro Postigo1, Carlos Marcuello1,2, William Verstraeten3,4

  • 1Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Ed. I+D+i. Mariano Esquillor, Zaragoza 50018, Spain.

Journal of the American Chemical Society
|January 27, 2025
PubMed
概括

这项研究引入了一种使用含有亚的多胺基的DNA纳米结构功能化的新方法. 这种DNA纳米技术方法可以通过高效的化学定制,为各种应用提供量身定制的特性.

更多相关视频

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
08:30

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

9.0K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

11.1K

相关实验视频

Last Updated: May 30, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.5K
Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
08:30

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

9.0K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

11.1K

科学领域:

  • 生物技术
  • 材料科学
  • 纳米技术

背景情况:

  • 通过自组装,DNA纳米技术可以创建复杂的纳米结构.
  • 化学修饰对于为特定应用量身定制DNA纳米结构至关重要.

研究的目的:

  • 开发一种用于指导DNA纳米结构的组装和功能化的新方法.
  • 使用含有亚的功能性聚胺来有效地化工装饰DNA原形.

主要方法:

  • 使用聚氨酸,辅助折叠基架DNA原形纳米结构与反应性亚基.
  • 通过应变促进的亚酸循环添加,以使含有二环氧的分子具有功能.
  • 加入一个基 (Cy5),聚乙烯甘醇 (PEG) 和一种疏水性酸乙烯胺 (PE) 标签.

主要成果:

  • 通过聚胺辅助成功折叠化基因原形.
  • 用Cy5,PEG和PE标签展示了DNA原型的装饰.
  • 建立了一个用于化学定制DNA纳米结构的多功能平台.

结论:

  • 开发的方法简化并降低了DNA纳米结构的化学定制成本.
  • 这种方法提高了DNA原型的多功能性和适用性.
  • 在DNA纳米技术中开辟了精确功能化的新途径.