肺功能对中晚年大脑的宏观和微观结构变化的影响
Jiao Wang1, Weige Xu2, Abigail Dove3
1Department of Epidemiology, College of Preventive Medicine,Third Military Medical University, Chongqing, China.
International journal of surgery (London, England)
|January 27, 2025
概括
肺功能不佳与大脑结构变化有关,例如大脑体积缩小和中晚年成年人白质完整性降低. 这表明潜在的神经退行性和血管影响.
科学领域:
- 神经科学是一个神经科学.
- 肺部病理学 肺部病理学
- 老年学是一门学科.
背景情况:
- 肺功能与认知衰退和痴呆症有关.
- 肺功能对大脑结构的影响尚未完全理解.
研究的目的:
- 调查肺功能与大脑结构变化之间的关联.
- 为了检查中后期生命中的宏观和微观结构性大脑变化.
主要方法:
- 利用了来自37164名参与者 (40-70岁) 的英国生物库数据.
- 通过复合得分 (FEV1,FVC,PEF) 评估肺功能.
- 通过回归和混合效应模型,分析了用于结构体积和扩散标记 (FA,MD) 的脑部MRI扫描.
主要成果:
- 低肺功能与较小的大脑体积 (总体,灰质,白质,海马) 和减少白质完整性相关.
- 在2.5年内,低肺功能显示白质/海马体积减少,FA降低,白质超强度体积增加和MD.
- 关联在各年龄组 (40-60岁和60岁以上) 中显著.
结论:
- 低肺功能与神经退行性和血管大脑病理有关.
- 这些大脑变化在中年和晚年的人群中都很明显.
- 强调呼吸系统健康对维持大脑结构的重要性.
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