Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Epigenetic Regulation01:46

Epigenetic Regulation

30.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
30.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Large-scale comparative genomics and structure-function analysis enables characterization of known and novel genetic determinants of antimicrobial resistance in bacterial pathogens.

Frontiers in microbiology·2026
Same author

Influenza coinfection inhibits control of mycobacterial infection in a human challenge model.

Nature communications·2026
Same author

Consensus Pituitary Atlas, a scalable resource for annotation, novel marker discovery, and analyses in mouse pituitary gland research.

Cell reports·2026
Same author

Etiology Model of Kawasaki Disease and Multisystem Inflammatory Syndromes: Mast Cell Activation.

Current issues in molecular biology·2026
Same author

Stage-aware transcriptomics reveals selective haplotype persistence in short-term <i>ex vivo</i> cultured <i>Plasmodium vivax</i>.

bioRxiv : the preprint server for biology·2026
Same author

Redundant and distinct mechanisms suppress innate immune activation during SARS-CoV-2 infection.

PLoS biology·2026
Same journal

Computational protocol for modeling supported nanoparticle catalysts with strong metal-support interactions.

STAR protocols·2026
Same journal

Protocol for genomic mapping of chromatin targets using high-throughput CUT&RUN.

STAR protocols·2026
Same journal

A protocol for noninvasive quantification of dietary fat absorption in mice.

STAR protocols·2026
Same journal

Protocol for an AlCl<sub>3</sub>-induced Alzheimer's model in zebrafish larvae with optimized pH and behavioral assessment.

STAR protocols·2026
Same journal

Protocol for live cell barcoding and immunophenotyping of human hematological malignancies using cytometry by time of flight.

STAR protocols·2026
Same journal

Generating drug resistance models in human and murine cancer cell lines and assessing cross-resistance to chemotherapeutics and KRAS inhibitors.

STAR protocols·2026
查看所有相关文章

相关实验视频

Updated: May 30, 2025

Optimization for Sequencing and Analysis of Degraded FFPE-RNA Samples
07:30

Optimization for Sequencing and Analysis of Degraded FFPE-RNA Samples

Published on: June 8, 2020

11.9K

关于表观遗传学和转录学数据质量控制的全面指南.

Arianna Comendul1, Frederique Ruf-Zamojski2, Colby T Ford3

  • 1Lincoln Laboratory, Massachusetts Institute of Technology, Lexington, MA, USA.

STAR protocols
|January 27, 2025
PubMed
概括
此摘要是机器生成的。

本指南为表观遗传学和转录组学试验提供了质量控制指标. 实施这些标准可以提高数据质量,以发现环境暴露特征.

关键词:
生物信息学是一种生物信息学.在RNAseqqq中使用.序列分析是指进行序列分析.

更多相关视频

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

1.4K
Chromatin Immunoprecipitation of Murine Brown Adipose Tissue
07:50

Chromatin Immunoprecipitation of Murine Brown Adipose Tissue

Published on: November 21, 2018

8.0K

相关实验视频

Last Updated: May 30, 2025

Optimization for Sequencing and Analysis of Degraded FFPE-RNA Samples
07:30

Optimization for Sequencing and Analysis of Degraded FFPE-RNA Samples

Published on: June 8, 2020

11.9K
In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

1.4K
Chromatin Immunoprecipitation of Murine Brown Adipose Tissue
07:50

Chromatin Immunoprecipitation of Murine Brown Adipose Tissue

Published on: November 21, 2018

8.0K

科学领域:

  • 环境健康 环境健康
  • 基因组学就是基因组学.
  • 分子生物学分子生物学

背景情况:

  • 宿主对环境暴露 (病原体,化学物质) 的反应涉及表观基因组和转录基因组的修改.
  • 检测技术的进步使得暴露特征的发现成为可能,包括代理物和时间.
  • 从生物样本中分析多个测试,单细胞数据是复杂的.

研究的目的:

  • 为表观遗传学和转录组学试验建立严格的质量控制 (QC) 标准.
  • 为11种不同的试验类型提供全面的质量控制指标套件.
  • 改进基准工作协议和数据集质量,以准确发现暴露特征.

主要方法:

  • 开发一套全面的质量控制指标.
  • 确定基础分析的质量保证标准.
  • 为失败的质量控制指标提供推的缓解措施.

主要成果:

  • 一份指南概述了11个表观遗传学和转录组学分析的QC指标.
  • 缓解措施来解决失败的指标.
  • 一个工作流程来提高数据集质量.

结论:

  • 标准化QC指标对于可靠的表观遗传学和转录学数据至关重要.
  • 改进的数据质量可以准确识别环境暴露特征.
  • 这本指南支持环境健康和分子生物学方面的强有力的研究.