氧化应激和肥胖与青少年内皮功能障碍和亚临床动脉样硬化有关
Josiane Aparecida de Miranda1, Warlley Rosa Cunha2, Júlio César Moraes Lovisi3
1Methodist College Granbery and UNIVERSO University Center Juiz de Fora MG Brazil.
Clinical biochemistry
|January 27, 2025
概括
青少年的肥胖与血管损伤的早期迹象有关,包括降低血管功能和增加动脉厚度. 氧化应激生物标志物在这些亚临床动脉样硬化变化中起着关键作用.
科学领域:
- 心血管研究研究心血管研究
- 儿科内分泌学 儿科内分泌学
- 氧化压力研究 研究 氧化压力研究
背景情况:
- 肥胖是青少年日益严重的全球健康问题.
- 内皮功能障碍和亚临床动脉样硬化是心血管疾病的早期指标.
- 氧化压力与血管损伤的发病有关.
研究的目的:
- 调查青少年肥胖和内皮功能障碍之间的关系.
- 评估氧化应激生物标志物在肥胖青少年亚临床动脉样硬化中的作用.
- 确定肥胖,氧化生物标志物和血管健康之间的关联.
主要方法:
- 一项涉及114名青少年 (年龄在12-17岁) 的横截面研究,来自巴西Juiz de Fora.
- 参与者被分为肥胖 (n=40) 和对照组 (n=74) 的两组.
- 测量包括臂膜流媒扩张 (BFMD),心动脉内膜介质厚度 (IMT) 和氧化生物标志物 (亚酸盐,酸盐,8-异质).
- 用多重回归分析来检查关联.
主要成果:
- 与对照人群相比,患有肥胖的青少年在动脉中显著减少了BFMD,增加了IMT.
- 在肥胖组中观察到高水平的8-异素 (表明氧化应激) 和较低的亚酸盐水平.
- 酸盐水平与IMT相反相关,这表明它具有保护作用.
结论:
- 青少年的肥胖与显著的早期血管变化有关,包括内皮功能障碍和亚临床动脉样硬化.
- 改变的氧化应激生物标志物与这些血管异常有关.
- 这些发现强调了监测肥胖青少年血管健康的重要性.
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