在免疫媒介炎症疾病的先进疗法之前,潜在结核病的评估和管理:综合性审查
Daya Krishna Jha1, Rinkalben Kakadiya2, Ananya Sharma3
1Gastroenterologist, INHS Kalyani, India.
Autoimmunity reviews
|January 27, 2025
概括
接受免疫抑制剂的免疫媒介性炎症疾病 (IMID) 患者面临更高的结核病 (TB) 风险. 早期检测和治疗潜伏结核病 (LTB) 对于防止其重新激活至关重要,特别是使用先进疗法.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 结核病 (TB) 是全球主要的传染性死亡原因.
- 免疫抑制,通常是免疫媒介炎症疾病 (IMID) 所需的,增加了对活性结核病的易感性.
- 潜在结核病 (LTB) 的重新激活是免疫功能低下的患者的一个重大问题.
研究的目的:
- 在接受IMID免疫抑制疗法的患者中审查结核病再激活的风险因素.
- 讨论潜伏结核病检测和治疗这一群体的策略.
- 突出目前LTB诊断测试的局限性.
主要方法:
- 审查有关结核病再激活风险因素的现有文献.
- 对潜在结核病检测的诊断策略的分析.
- 在免疫功能低下患者中评估潜伏结核病的治疗方法.
主要成果:
- TNF 抑制剂和 JAK 抑制剂对结核病再激活的风险最高.
- 目前对LTB的诊断测试在灵敏度和预测价值上有局限性.
- 免疫学测试和LTB等效 (临床,放射学) 的组合可以改善亚临床结核病检测.
结论:
- 在开始IMID免疫抑制疗法之前或期间,对LTB进行主动查和治疗至关重要.
- 需要地理上适当的测试策略.
- 需要进一步改进LTB诊断以更好地预测重新激活风险.
关键词:
结性脊柱炎是一种疾病.抗IL12/2323的使用情况.抗IL2323的使用方法抗TNFs的使用方法抗整合素是一种抗整合素.炎症性肠病是一种炎症性肠病.潜伏性结核病 潜伏性结核病牛皮病是什么意思 牛皮病类风湿性关节炎 类风湿性关节炎 类风湿性关节炎更多相关视频
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