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在怀孕期间的过渡性多尿症中,阿尔金因压素调节的基础是补偿机制
Tetsuro Tsumura1, Daisuke Hagiwara1, Satoshi Naito1
1Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
怀孕引起的多尿症发生时,胎盘血压酶降解了阿尔金因血压素 (AVP),压倒了身体的补偿性AVP释放. 这项研究在小鼠中研究了这种机制.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 腎臟病學 (nephrology) 是一種醫學.
- 分子内分泌学分子内分泌学
背景情况:
- 怀孕期间的过渡性多尿症与由胎盘血压酶降解的氨酸血压素 (AVP) 降解的增加有关.
- 驱动这种与怀孕相关的多尿症的确切机制尚不清楚.
研究的目的:
- 用小鼠模型研究血管压酶在怀孕引起的多尿症中的作用.
- 检查怀孕期间AVP调节的补偿机制.
主要方法:
- 在怀孕期间测量尿液体积,尿液度和AVP转录活性 (Avp hnRNA) 在野生类型和家族神经垂体糖尿病无味症 (FNDI) 小鼠中.
- FNDI小鼠作为部分AVP缺乏的模型.
主要成果:
- 在怀孕小鼠的胎盘中检测到血管压酶.
- 在怀孕晚期的野生型和FNDI小鼠中,超视核中的AVP转录活性被上调.
- 只有FNDI小鼠在怀孕期间表现出尿量显著增加和尿液度下降.
结论:
- 在怀孕期间,当AVP释放的补偿性增加无法克服血管压酶介导的降解时,就会观察到尿量增加.
- 这表明一个值效应,即AVP水平不足导致多尿症,尽管AVP转录的上调.
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