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在外周性角膜炎的临床结果
Krishna Mallem1, Paulina Liberman2, Meghan K Berkenstock2
1From the Wilmer Eye Institute, the Department of Ophthalmology, the Johns Hopkins University School of Medicine (K.M., P.L., M.K.B., J.T.W., B.B.B., D.A.J., J.E.T), Baltimore, Maryland, USA; Drexel University College of Medicine (K.M.), Philadelphia, Pennsylvania, USA.
American journal of ophthalmology
|January 27, 2025
概括
系统治疗有效控制了周围性角膜炎 (PUK),并允许大多数患者减少皮质类固醇. 然而,在这个研究队列中,实现PUK持续无药缓解仍然具有挑战性.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 周围性角膜炎 (PUK) 是一种严重的眼部疾病,通常与系统性自身免疫性疾病有关.
- 有效的管理策略至关重要,以防止视力丧失和全球完整性.
研究的目的:
- 评估患有外周性角膜炎 (PUK) 的患者的临床特征和治疗结果.
- 评估全身疗法在治疗PUK的有效性,包括疾病控制和皮质类固醇戒断.
主要方法:
- 采用了回顾性病例系列设计,分析了2003年至2022年间被诊断患有PUK的57名患者的数据.
- 数据包括患者人口统计,全身性疾病关联,疾病横向性,PUK活性,角膜穿孔和治疗方案.
- 评估的关键结局是疾病控制,皮质类固醇节约和停药成功,持续的无药缓解,疾病再激活和需要手术.
主要成果:
- 所有患者通过全身疗法在平均1.3个月内实现了疾病控制.
- 皮质类固醇缓存和停止治疗的成功率分别为0.44和0.27个患者年.
- 只有6%的患者实现了持续的无药缓解,疾病复活率为每年0.07%.
结论:
- 系统疗法在实现疾病控制和促进PUK患者的皮质类固醇减少方面是有效的.
- 虽然最初的疾病控制是可以实现的,但持续的无药缓解是罕见的,这凸显了许多人的慢性病情.
- 即使在初始控制建立之后,对疾病的重新激活进行密切监测是必不可少的.
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