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患有慢性乙型肝炎感染的母亲患者报告的结果:横截面分析

Shi OuYang¹, Yueying Deng², Yawen Geng³

¹Department of Infectious Diseases, Key Laboratory of Biological Targeting Diagnosis, Therapy, and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.

Clinics and research in hepatology and gastroenterology

|January 27, 2025

概括

患有慢性乙型肝炎 (CHB) 的孕妇经历了生活质量的降低,特别是在担心和社会功能方面. 冠状动脉瘤感染独立预测这些损伤,强调需要综合护理.

科学领域:

孕产妇健康孕产妇健康
肝病学肝病学是一种肝病学.
生活质量研究研究生命质量研究

背景情况:

在患有慢性乙型肝炎 (CHB) 的孕妇中,与健康相关的生活质量 (HRQoL) 尚未得到充分证实.
患者报告的结果 (PROs) 提供了宝贵的见解,了解母亲在怀孕期间的生活经历.

研究的目的:

为了在怀孕期间比较患有CHB的母亲和健康母亲之间的PROs.
在孕妇CHB患者中确定影响HRQoL的因素.

主要方法:

在2023年4月至7月期间,一项涉及257名孕妇 (100名CHB,157名对照) 的横截面研究.
使用36项简短形式调查 (SF-36) 和慢性肝病问卷 (CLDQ) 进行PRO评估.
统计分析包括奇平方测试和多重线性回归.

主要成果:

与健康的母亲相比,CHB母亲在CLDQ"担忧"领域和SF-36"社会功能"领域报告了显著更差的HRQoL.
高水平的HBVDNA (>200,000 IU/mL) 与CHB母亲的PROs较差有关.
损伤HRQoL的独立预测因素包括CHB感染,严重的恶心/吐,恶劣的生活条件和负面的配偶态度.

结论:

怀孕期间的慢性乙型肝炎感染会对母亲的HRQoL产生负面影响,特别是影响焦虑和社会功能.
CHB感染是PRO损伤的独立预测因素.
孕妇CHB母亲的管理应整合HRQoL的监测和干预.

关键词:

36项简短形式的调查调查慢性肝病问卷问卷慢性肝病问卷乙型肝炎病毒病的病毒病.在怀孕期间感染B型肝炎社会功能受损社会功能受损

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