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低出生体重和慢性病,在儿童中进展到功能衰竭
Fu-Shun Yen1, James Cheng-Chung Wei2,3,4,5, Wan-Yin Cheng6
1Dr Yen's Clinic, Taoyuan, Taiwan.
低出生体重 (LBW),早产和小于妊娠年龄 (SGA) 显著增加儿童患慢性病 (CKD) 和末期病 (ESKD) 的风险. 这些因素,特别是当它们结合在一起时,在生命早期对脏健康构成协同威胁.
科学领域:
- 儿科脏病学 儿科脏病学
- 围产儿医学 围产儿医学
- 公共卫生 公共卫生
背景情况:
- 低出生体重 (LBW),早产和小于妊娠年龄 (SGA) 对儿童慢性病 (CKD) 和末期病 (ESKD) 的独立和联合影响仍然不清楚.
- 宫内生长限制和早产是众所周知的各种不良健康结果的风险因素,但它们对长期功能的具体影响需要进一步调查.
研究的目的:
- 调查LBW,早产和SGA对儿童患CKD和ESKD风险的个人和协同影响.
- 通过大规模的队列研究量化与这些围产期疾病相关的过度风险.
主要方法:
- 一项使用台湾母婴健康数据库的队列研究,包括2009年至2016年间出生的1477,128名新生儿.
- 用多变量考克斯回归模型来评估CKD和ESKD的风险.
- 婴儿从出生至2018年12月31日进行了随访,平均随访时间为5.78年.
主要成果:
- 低出生体重 (LBW) 与男性和女性婴儿中CKD和ESKD风险增加有关.
- 患有LBW的男性婴儿显示CKD的HR为1.20,ESKD的HR为1.64.
- 除了LBW外,早产和SGA条件表明,与满期婴儿相比,CKD和ESKD风险的显著和协同增加.
结论:
- 出生于LBW,早产或SGA的儿童面临患有CKD和ESKD的风险显著增加.
- 这些围产期因素有助于长期病风险,突出显示了对受影响儿童的监测和潜在干预的重要性.
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