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自主神经系统和慢性病中的炎症
Carmine Zoccali1,2,3, Francesca Mallamaci4,5, Mehmet Kanbay6
1Renal Research Institute, NY, USA.
恢复自主神经系统的平衡,特别是交感神经系统和副交感神经系统,是减少慢性病和心血管疾病的炎症的关键.
科学领域:
- 生理学 生理学 生理学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 自主神经系统,包括交感神经系统 (SNS) 和副交感神经系统 (PNS),调节平衡.
- 自主调节失调,随着SNS的增加和PNS活动的减少,在慢性病 (CKD) 和心血管疾病 (CVD) 中很普遍.
- 这种不平衡促进炎症,恶化疾病进展和心血管事件风险.
研究的目的:
- 探索自主神经系统调节失调在与CKD和CVD相关的炎症中的作用.
- 审查针对自主平衡的治疗策略,以管理炎症和改善结果.
主要方法:
- 关于自主神经系统功能,炎症,CKD和CVD的研究的文献综述.
- 对影响自主平衡的药理和生活方式干预措施的分析.
- 作为一种治疗方法,对迷走神经刺激的检查.
主要成果:
- 脑神经系统的激活通过甲基荷胺增加炎症;脑神经系统的激活通过胆固醇抗炎途径减少炎症.
- 药物制剂 (β-阻断剂,ACEi,ARB) 和生活方式干预可以调节自主活动和炎症.
- 迷你神经刺激在减少炎症和改善各种疾病的结果方面表现有希望,尽管心力衰竭试验结果混合.
结论:
- 恢复神经神经系统和神经神经系统之间的自主平衡是减少CKD和CVD炎症的有希望的策略.
- 针对自主神经系统为新的治疗方法提供了潜力,以改善患者的治疗结果.
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