在胆管癌中,三级淋巴体结构和瘤透淋巴细胞的比较影响
Shin-Yi Chung1, Yi-Chen Yeh2,3,4, Chien-Jung Huang2
1Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.
Journal for immunotherapy of cancer
|January 27, 2025
概括
三级淋巴体结构 (TLS) 是在胆管癌 (CCA) 中更好的免疫疗法反应的生物标志物. 它们的存在表明瘤炎症和改善患者的结果,表明TLS作为治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 胆管癌 (CCA) 对常规疗法,包括免疫检查点抑制剂的反应有限.
- 瘤透淋巴细胞 (TIL) 和三级淋巴细胞结构 (TLS) 在瘤微环境 (TME) 中至关重要,但它们在CCA免疫中的独特作用尚不清楚.
研究的目的:
- 阐明TLS和TIL在CCA瘤微环境中的不同作用.
- 为了研究TLS对CCA患者免疫治疗反应的预测价值.
主要方法:
- 分析了16个CCA瘤样本,这些样本来自nivolumab的II期试验,再加上改性gemcitabine和S-1.
- 免疫组织化学和RNA测序用于评估TLS和TIL.
- GeoMx数字空间分析仪和癌症转录组图谱用于差异基因表达和免疫细胞组成分析.
主要成果:
- 与TLS阴性患者 (N=9) 相比,TLS阳性患者 (N=7) 的免疫治疗结果明显更好 (ORR 71%,DCR 100%).
- TLS存在与改善无进展和整体存活率相关 (p=0.03) 并与富含T和B细胞的炎症瘤相关.
- TLS显示出更高的B细胞相关基因表达,记忆B细胞和髓状树突细胞,而TLS阳性瘤中的TIL显示出更高的疲劳特征和PD-1/LAG-3表达.
结论:
- 在胆管癌中,TLS是有利的免疫疗法反应的重要预测因子.
- TLS代表了一个潜在的生物标志物和治疗点,用于提高CCA的治疗疗效.
- 在TLS阳性瘤中的TIL显示出明显的耗尽的T细胞特征和升高的PD-1/LAG-3表达,支持临床发现.
相关概念视频
01:27Tumor Immunotherapy
466
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
466
02:17The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K