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Updated: May 30, 2025

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
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Published on: April 29, 2010

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酸化依赖的WRN-RPA相互作用促进了二级DNA结构中停滞的分叉的恢复

Alessandro Noto1,2, Pasquale Valenzisi1, Flavia Di Feo1

  • 1Mechanisms, Biomarkers and Models Section - Genome Stability Group, Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena, 299 - 00161, Rome, Italy.

Nature communications
|January 27, 2025
PubMed
概括

通过解决G4结构,WRN-RPA复合体对于修复停滞的DNA复制分叉至关重要. 它的缺失导致DNA间隙和双链断裂,突出显示了WRNN.

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