相关实验视频

Updated: May 30, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

对中度和重度牛皮之间的蛋白质学差异的横截面研究

Lingling Wu¹, Chen Cen¹, Bibo Xie¹

¹Department of Dermatology, Dermatology Hospital of Zhejiang Province, Huzhou, 313299, China.

Scientific reports

|January 27, 2025

概括

蛋白质组分析显示了中度和重度牛皮之间的显著差异. 与炎症和免疫反应途径相关的关键蛋白质可以作为疾病严重程度的生物标志物.

科学领域:

蛋白质组学是指蛋白质组学.
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

牛皮病 (PV) 的发病因子尚未完全理解,特别是中度和严重形式之间的蛋白质组区别.
识别这些差异对于了解疾病进展和开发向疗法至关重要.

研究的目的:

为了研究中度和重度牛皮的蛋白质组概况.
确定与疾病严重程度相关的差异表达蛋白 (DEPs) 和相关途径.

主要方法:

使用数据独立获取质谱法 (DIA-MS) 进行横截面研究,以比较中度和重度牛皮的蛋白质表达.
用发明路径分析 (IPA) 和4D并行反应监测 (4D-PRM) 来进行进一步分析.

主要成果:

在中度至重度的牛皮之间,确定了173个DEP (85个上调,88个下调).
18个DEP在包括IL-17信号传递,中性粒细胞外细胞陷形成,中性粒细胞脱粒化和NF-κB信号传递在内的途径中得到显著丰富.
鉴定TNF和TDP53是顶级上游调节剂,而脂多糖和YAP1是潜在的下游调节剂.

结论:

该研究确定了18个DEP作为牛皮严重程度的潜在生物标志物,与关键的炎症和免疫反应途径有关.
准这些已识别的蛋白质和管理相关感染可能会改善牛皮的严重程度和治疗结果.

关键词:

4D平行反应监测生物标志物生物标志物数据独立采集质谱测量独创性路径分析蛋白质组学是指蛋白质组学.牛皮一般的牛皮.

更多相关视频

Proteomic Profiling of Macrophages by 2D Electrophoresis

Proteomic Profiling of Macrophages by 2D Electrophoresis

Published on: November 4, 2014

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

相关概念视频

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...