作为COVID-19治疗的标签外消费的兽医产品中ivermectin的量化
C Wentzel1, N Gernandt1, M Gerber1
1Centre of Excellence for Pharmaceutical Sciences (Pharmacen™), North-West University, Potchefstroom, Republic of South Africa.
Die Pharmazie
|January 27, 2025
概括
在COVID-19期间使用的兽医ivermectin产品进行了含量测试. 所有产品都含有可接受限度内的ivermectin,但由于安全问题,强烈不建议在人身上使用.
科学领域:
- 制药科学 制药科学
- 分析化学 分析化学
- 兽医药理学 兽医药理学
背景情况:
- 在COVID-19大流行期间,广泛使用非标签的ivermectin,包括兽医配方.
- 艾弗梅克丁是一种宏环乳,主要用于兽医.
- 人们对人类使用的兽医ivermectin产品的安全性和有效性表示担忧.
研究的目的:
- 开发和验证一种快速的高性能液体染色学 (HPLC) 方法来定量ivermectin.
- 为了分析COVID-19大流行期间使用的兽医产品中的ivermectin含量.
- 为了与产品标签上的说法比较测量的ivermectin水平.
主要方法:
- 开发和验证一个快速的HPLC方法.
- 收集本地使用和商业兽医ivermectin产品.
- 使用验证的HPLC方法量化ivermectin.
- 量化ivermectin含量与标签声明的比较.
主要成果:
- 所有经过测试的兽医ivermectin产品都在可接受的范围内含有ivermectin.
- 开发的HPLC方法被证明是快速和有效的ivermectin量化.
- 在标签声明和实际的甲含量之间没有发现任何显著的差异.
结论:
- 虽然经过测试的兽医ivermectin产品符合标签声明,但不建议在人类中非标签使用.
- 兽医产品中的高剂量和注射途径可能会导致人类的不良反应.
- 未经验证的辅助剂和其他活性成分的存在会给健康带来未知的风险.
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