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美国献血者中梅毒阳性和错误阳性趋势,2013-2023年

Galen Conti¹, Rahima Fayed¹, Paula Saa¹

¹American Red Cross, Rockville, Maryland, USA.

|January 27, 2025

概括

美国献血者中梅毒感染率正在增加,反映了人口趋势. 假阳性 (FP) 梅毒捐赠显示经常出现的季节性峰值和高频率的FP结果重复.

科学领域:

传染性疾病传染性疾病
公共卫生公共卫生
输血医学输血医学

背景情况:

梅毒是一种输血传染性感染,需要对美国的献血者进行查.
这项研究分析了11年间梅毒感染和假阳性 (FP) 捐赠的趋势.

研究的目的:

描述美国献血者中梅毒感染 (最近和过去) 和FP捐献的纵向趋势.
评估与梅毒反应性和FP结果相关的捐赠者人口统计和特征.

主要方法:

从2013年1月1日到2023年12月31日,分析了大约5300万个美国红十字会献血的数据.
使用三角膜和非三角膜血清学测试对梅毒状况的分类.
对梅毒感染和FP捐赠的流行情况,捐赠者特征和纵向趋势的评估.

主要成果:

总共有10,365例梅毒感染 (0.02%) 和48,719例FP捐赠 (0.09%) 被确定.
最近的梅毒感染病例在过去11年中呈现出不断增加的趋势.
有FP捐赠的捐赠者出现了随后梅毒阳性和FP捐赠的高率,FP事件之间的中位时间为3.6个月.

结论:

献血者的梅毒感染率正在上升,与美国人口趋势一致.
假阳性梅毒捐赠者具有重复FP结果和不明原因的阳性捐赠的显著风险.
观察到季节性FP峰值,但在研究期间显示下降趋势.

关键词:

献血者献血者献血者献血者献血者假阳性测试结果的测试结果.梅毒感染梅毒感染

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