跨直流刺激和抑制控制训练对中风后个人抑郁和焦虑的影响
Csaba Kazinczi1,2, Noemi Szepfalusi3, Viola Luca Nemeth3
1Department of Neurology, University of Szeged, 6, Semmelweis Street, Szeged, 6725, Hungary. kazinczi.csaba@med.u-szeged.hu.
BMC neurology
|January 28, 2025
概括
将跨直流刺激 (tDCS) 与抑制控制训练 (ICCT) 结合起来,在中风幸存者中显著降低了抑郁症状. 两种治疗单独都没有对情绪障碍产生显著影响.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 康复医学 康复医学 康复医学
背景情况:
- 在情绪障碍中,前额双脑脑网络和认知控制至关重要.
- 跨直流刺激 (tDCS) 和认知训练被用于中风康复.
- 脑卒中后的抑郁和焦虑是患者康复的重要问题.
研究的目的:
- 为了研究基于计算机的抑制控制训练 (ICCT) 和阳道tDCS的联合效果.
- 评估对中风后抑郁和焦虑症状的影响.
主要方法:
- 35名参与者被随机分为三个组:积极的tDCS (A),模拟的tDCS与ICCT (T),或积极的tDCS与ICCT (AT).
- 干预持续了十天.干预持续了十天.
- 主要结局包括贝克抑郁 inventory (BDI),汉密尔顿抑郁评分表 (HAM-D) 和斯皮尔伯格的状态特征焦虑 inventory (STAI-S/T).
- 统计分析涉及混合模型差异分析和贝叶斯分析.
主要成果:
- 与ICCT (AT) 组一起的活跃tDCS显示,贝克抑郁 inventory (BDI) 评分显著降低 (p < .001).
- 在任何组中都没有观察到HAM-D,STAI-T或STAI-S得分的显著改善.
- 个别治疗 (A或T) 没有显著改善情绪.
结论:
- 根据BDI得分,tDCS和ICCT的组合有效地减少了抑郁症状.
- tDCS和ICCT之间的协同作用需要进一步研究,以治疗中风后情绪障碍.
- 需要进一步的研究来阐明这些联合治疗效应的潜在机制.
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