循环节律的扰乱加剧了老鼠上性牙周炎的膜骨损失
Lanxiang Ye1,2,3, Gang Mei1,2,3, Huan Liu4
1Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
International endodontic journal
|January 28, 2025
概括
循环节律的干扰加剧了顶端牙周炎和膜骨损失. 用黑激素恢复昼夜节律可能有助于牙科患者的愈合.
科学领域:
- 口腔生物学 口腔生物学
- 时间生物学 时间生物学
- 炎症性疾病是一种炎症性疾病.
背景情况:
- 循环节律扰乱 (CRD) 影响生物钟基因,如BMAL1,影响炎症反应.
- 对于CRD在常见的口腔炎症状况 - - 顶端牙周炎的发病过程中的作用尚不清楚.
- 研究CRD对顶性牙周炎的影响可以提供新的治疗策略.
研究的目的:
- 调查昼夜节律扰乱对顶端牙周炎的影响.
- 阐明将CRD与顶端牙周炎联系起来的致病机制.
- 评估黑激素作为CRD诱导的尖端牙周炎的潜在治疗剂.
主要方法:
- 在患有尖端牙周炎的患者中进行横截面研究.
- 在老鼠中结合CRD和顶端牙周炎的动物模型.
- 评估周周气泡骨破坏 (微型CT,H&E,TRAP染色).
- 生物钟基因表达的分析 (RT-qPCR,免疫组织化学).
- 评估Bmal1淘汰赛大鼠和黑激素治疗以恢复节律.
主要成果:
- 慢性牙周病 (CRD) 与慢性牙周炎 (CAP) 的急性恶化有关.
- 在顶端牙周炎模型中,CRD加剧了炎症性压力和膜骨损失.
- 在周围组织中观察到时钟基因,特别是Bmal1的表达受损.
- 缺乏Bmal1会加剧炎症和骨破坏;黑激素治疗减轻了这些影响.
结论:
- CRD是一种新型的因素,可加剧炎症和膜骨损失在顶端牙周炎.
- 黑色素显示承诺作为一个辅助疗法在牙周边的牙周炎的牙周周围组织愈合.
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