基于凝的粘合水凝具有自我愈合,可注射和温度触发的可脱离性质
Jingjing Zhou1, Han Cui1, Sichen Li1
1School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.
Macromolecular bioscience
|January 28, 2025
概括
研究人员开发了新的基于凝的水凝. 这些材料提供可调节的附着性,可无痛移除,对于诸如伤口愈合和组织工程等应用至关重要.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 组织工程是组织工程.
背景情况:
- 粘合性水凝对组织工程和伤口愈合有希望.
- 当前的水凝可以在去除时引起疼痛和二次损伤.
研究的目的:
- 开发基于凝的水凝,具有可调和易拆卸的粘合性能.
- 为了研究温度和酸氧化对水凝粘附的影响.
主要方法:
- 合成了基于凝的水凝,使用酸和4-甲基酸交叉链接.
- 为水凝网络形成了动态共价乙烯和胺胺键.
- 研究了水凝的特性,包括在不同温度和氧化状态下对猪皮肤的自我愈合,可注射性和粘合强度.
主要成果:
- 水凝表现出自我愈合和可注射的特性.
- 粘附强度可以根据温度和酸氧化程度进行调整.
- 在37°C (中等氧化) 时的最大附着力为30kPa,在25°C下降至≈10kPa,使得可无痛移除.
结论:
- 介绍了一种用于设计具有可定制粘合性的功能性水凝的新方法.
- 开发的水凝为少入侵的生物医学应用提供了有希望的解决方案.
- 可调节的附着性是平衡材料性能和患者舒适性的关键.
相关概念视频
Adhesion
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Cohesion
Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a surface,...
On a surface,...
Dehydration Synthesis
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.Synthesis of carbohydratesSugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from one reactant...
Hydrolysis
Overview
Hydrolysis is a chemical reaction in which the addition of water breaks down a polymer into its simpler monomer units. For example, peptides break into amino acids, carbohydrates into simple sugars, and DNA into nucleotides. Enzymes often facilitate these processes.
Hydrolysis Reverses Dehydration Synthesis
Complex carbohydrates can be broken down by breaking the bonds between individual sugar units. The reaction breaks a glycosidic bond as water is added to the compound. The...
Hydrolysis is a chemical reaction in which the addition of water breaks down a polymer into its simpler monomer units. For example, peptides break into amino acids, carbohydrates into simple sugars, and DNA into nucleotides. Enzymes often facilitate these processes.
Hydrolysis Reverses Dehydration Synthesis
Complex carbohydrates can be broken down by breaking the bonds between individual sugar units. The reaction breaks a glycosidic bond as water is added to the compound. The...
Drying Shrinkage
When hardened concrete is exposed to air with a relative humidity of less than 100 percent, it begins to lose the free water within its capillaries. As this water evaporates, the water initially adsorbed onto the calcium silicate hydrates migrates towards these now empty spaces and eventually evaporates as well. Over time, as more water leaves, the volume of the concrete decreases, a phenomenon known as drying shrinkage.
A portion of this drying shrinkage can be reversed; if the concrete is...
A portion of this drying shrinkage can be reversed; if the concrete is...


