揭示了表面水源中溶解有机物及其细胞毒性之间的分子联系,这些细胞毒性受到化消毒的影响
Huihui Hong1, Hai Huang2, Sheng-Ao Li2
1Department of Environmental Medicine, School of Medicine, Chongqing University, Chongqing 400045, China.
Environmental science & technology
|January 28, 2025
概括
化将溶解的有机物 (DOM) 转化为消毒副产品 (DBPs). 这项研究揭示了选择性的DOM变化,并将红素和蛋白质化合物与细胞毒性联系起来,强调需要去除有毒物质.
科学领域:
- 环境化学环境化学
- 水处理科学水处理科学
- 毒理学 毒理学 毒理学
背景情况:
- 溶解有机物 (DOM) 是在水过程中形成的消毒副产品 (DBPs) 的关键前体.
- 了解DOM转换及其与DBP细胞毒性的联系对于公共卫生至关重要.
研究的目的:
- 在各种地表水中化过程中研究分子水平的DOM变化.
- 使用预测性毒理学评估,将DOM组合与DBP细胞毒性相关联.
主要方法:
- 用于DOM表征的高分辨率质谱学.
- 对DBP进行预测性毒理学评估的替代方法.
- 在DOM成分和细胞毒性之间的相关性分析.
主要成果:
- 观察到DOM的选择性化,优先转化素和类似蛋白质的化合物.
- 反应性顺序:红素 > 蛋白质 > 素/ConAC.
- 细胞毒性主要与素和类似蛋白质的化合物 (CHO,CHNO组) 相关.
- 线粒体损伤被确定为DOM诱导细胞毒性的敏感指标.
- 确定了37种常见的毒性驱动的DBP成分 (低质量,中等H/C,低O/C,减少状态,疏水性).
结论:
- 化显著改变了DOM结构,影响了DBP的形成和毒性.
- 红素和蛋白质分量是DOM衍生的细胞毒性的主要贡献者.
- 针对性地去除特定的DOM前体对于减轻DBP健康风险至关重要.
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