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光生物调节对燃烧口腔综合征的影响:系统性审查和元分析
Monica Reiko Okuhara1, Virgínia Fernandes Moça Trevisani1, Cristiane Rufino Macedo1
1Universidade Federal de São Paulo-Escola Paulista de Medicina-UNIFESP-EPM, São Paulo, Brazil.
Journal of oral rehabilitation
|January 28, 2025
概括
相比于安慰剂和克洛纳泽帕姆,光生物调节或低水平激光疗法减少了口腔炎综合征患者的疼痛,改善了他们的生活质量. 然而,证据质量较低,需要进一步研究.
科学领域:
- 口腔医学是指口腔医学.
- 再生医学是一种再生医学.
- 基于证据的牙科.
背景情况:
- 燃烧口腔综合征 (BMS) 是一种慢性疼痛疾病,治疗选择有限.
- 光生物调节疗法 (PBMT),也称为低水平激光疗法 (LLLT),正在作为BMS的潜在治疗方法进行探索.
- 这项研究系统地审查了PBMT对BMS的疗效和安全性.
研究的目的:
- 评估PBMT (或LLLT) 治疗燃烧口腔综合征 (BMS) 的有效性和安全性.
- 为了比较PBMT结果与安慰剂,克罗纳泽帕姆和阿尔法-酸治疗.
- 评估PBMT对BMS患者疼痛缓解,口腔健康生活质量和心理健康的影响.
主要方法:
- 进行了随机临床试验 (RCT) 的系统审查和元分析.
- 搜索包括主要的数据库 (MEDLINE,CENTRAL,LILACS,EMBASE) 和临床试验注册表,截至2023年4月.
- 数据提取和偏差风险评估由两个独立的审稿人进行,随机效应建模用于元分析.
主要成果:
- 与安慰剂 (红色和红外激光) 和克洛纳泽帕姆相比,PBMT显示疼痛显著减少.
- 口腔健康生活质量改善了PBMT与安慰剂相比,尽管证据质量非常低.
- 在PBMT和安慰剂或克洛纳泽帕姆组之间,在焦虑或抑郁水平上没有发现显著差异.
结论:
- 与安慰剂和克洛纳泽帕姆相比,低水平激光疗法在减少BMS患者的疼痛和改善BMS患者的生活质量方面似乎有效.
- 目前支持这些发现的证据的确定性低至非常低.
- 需要进一步进行高质量的随机临床试验来证实这些结果并增加证据的确定性.
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