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相关概念视频

Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Microbes in Food Production01:29

Microbes in Food Production

Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...
Microbes in the Production of Fermented Foods01:27

Microbes in the Production of Fermented Foods

Lactic acid bacteria (LAB) and molds are instrumental in fermenting plant-based foods to enhance preservation and ensure year-round availability. These microbial processes convert plant carbohydrates into organic acids and other metabolites that inhibit spoilage organisms and contribute to the sensory qualities of the final product.In sauerkraut production, cabbage goes through a microbial succession that starts with cocci such as Leuconostoc mesenteroides. These microbes begin fermentation by...
Probiotics01:22

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Production of Organic Acids01:25

Production of Organic Acids

Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...

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相关实验视频

Updated: May 14, 2026

Generation of Alginate Microspheres for Biomedical Applications
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珍珠:蛋白质排泄酸与复合乳酸菌.

Varun Sai Tadimarri1,2, Marc Blanch-Asensio1,2, Ketaki Deshpande1,2

  • 1INM - Leibniz Institute for New Materials, Saarland University, Campus D2 2, 66123, Saarbrücken, Germany.

Small (Weinheim an der Bergstrasse, Germany)
|January 28, 2025
PubMed
概括

在酸盐珠中使用益生菌乳酸菌的工程生物材料 (ELM) 可使蛋白质持续释放14天. 这种PEARL系统提供细菌制和稳定的治疗输送.

关键词:
酸是一种酸.工程生物材料是生物材料.乳酸菌种 (lactobacillus) 是一种乳酸菌.这是一种分泌的分泌物.合成生物学 合成生物学

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Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability
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科学领域:

  • 生物技术是生物技术.
  • 材料科学 材料科学 材料科学
  • 微生物学 微生物学

背景情况:

  • 在水凝中使用细菌的工程生物材料 (ELM) 显示出治疗应用的前景.
  • 乳酸细菌,特别是乳酸菌,由于其固有的健康益处,受到益生菌的青.
  • 乳杆菌中有限的遗传工具阻碍了它们在先进的ELM中使用.

研究的目的:

  • 为了提高Lactiplantibacillus plantarum WCFS1对蛋白质分泌的遗传可编程性.
  • 开发一个具有成本效益和生物相容的核心外的酸珠,用于封装工程乳酸菌.
  • 创建一种新的ELM,用于控制和持续释放重组蛋白质.

主要方法:

  • 为了增强蛋白质分泌,对Lactiplantibacillus plantarum WCFS1进行基因工程.
  • 在核心外的酸珠中封装工程细菌.
  • 评估14天内的蛋白质释放概况和细菌制.

主要成果:

  • 在L. plantarum WCFS1中成功扩展了蛋白质分泌的遗传可编程性.
  • 开发PEARL (蛋白质脱落酸与重组乳球菌),一种新的ELM.
  • 已证明可以控制和持续释放重组蛋白长达14天.
  • 封装的观察到的好处,包括细菌制和稳定释放配置文件.

结论:

  • 在酸盐珠中封装的重组乳酸菌提供了治疗性蛋白质输送的可行策略.
  • 皮尔系统提供了互惠的好处,增强了细菌功能和蛋白质释放特征.
  • 这种方法克服了乳杆菌遗传工具的局限性,用于开发先进的ELM.