双驱动生物降解纳米电机,用于增强细胞吸收
Jianhong Wang1, Andreas Polyviou1, Jari F Scheerstra1
1Bio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands. J.Shao@tue.nl.
Journal of materials chemistry. B
|January 28, 2025
概括
这项研究引入了新的混合纳米发动机,使用双推进方法,用于增强的生物医学应用. 这些纳米电机由近红外光和催化反应驱动,在瘤细胞中显示出更好的积累.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 混合纳米发动机为生物医学应用提供可控制的运动机.
- 目前的纳米发动机通常依赖于单一的推进模式,在复杂的生物环境中限制了效率.
- 双刺激响应纳米电机可以增强活体中的运动性和向性.
研究的目的:
- 为改善生物医学应用开发具有双推进机制的混合纳米电机.
- 为了研究等离子体加热和催化转换对纳米电机驱动的联合效应.
- 为了增强瘤细胞内的纳米运动积累,以便有针对性的输送.
主要方法:
- 生物降解性胃细胞的功能化与纳米颗粒 (Pt NPs).
- 利用近红外 (NIR) 激光照射进行等离子体加热和温度梯度生成.
- 利用Pt NPs的催化特性将过氧化 (由葡萄糖氧化酶产生) 转化为氧和水,用于化学梯度推进.
主要成果:
- 混合纳米发动机展示了双推进机制,对NIR激光和化学刺激都有反应.
- 不对称的胃细胞形状与 Pt NPs 结合,为推进创造了有效的温度梯度.
- 葡萄糖氧化酶的联合封装使局部过氧化的产生成为可能,推动了催化推进.
- 由于它们的运动特征,在瘤细胞内观察到纳米电机的增强积累.
结论:
- 开发的混合纳米发动机表现出多功能双刺激响应运动.
- 这种设计为复杂的生物医学环境中更有效地运行纳米载体提供了有希望的方法.
- 这些纳米发动机显示出在瘤细胞中增强向传递和积累的潜力.
相关概念视频
01:24Modified-Release Drug Delivery Systems: Site-Targeted
164
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
164
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160