相关实验视频

Updated: May 30, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

血清干细胞衍生因子1α作为急性髓性白血病的老年患者接受CAG化疗的预后指标

Zhenzhen Wang¹, Jing Yuan¹, Nan Zhou¹

¹Department of Hematology, the Second Hospital of Hebei Medical University, Hebei, Shijiazhuang, China.

Frontiers in oncology

|January 28, 2025

概括

在老年急性髓性白血病 (AML) 患者中,肌细胞衍生因子1 (SDF-1) 的升高与化疗反应不佳和生存率降低相关. SDF-1可以作为治疗结果的预后生物标志物.

科学领域:

血液学血液学血液学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

干细胞衍生因子1 (SDF-1) 是血液形成的组成部分,并与急性髓性白血病 (AML) 病原发生有关.
研究SDF-1在化疗结果中的作用可以完善老年AML患者的治疗策略.

研究的目的:

评估血清SDF-1α水平与老年AML患者的化疗反应之间的关联.
确定血清SDF-1α是否可以作为该人口群体治疗结果的预后标记.

主要方法:

对187名老年AML患者和120名年龄相匹配的对照进行了回顾性分析.
用ELISA测量血清SDF-1α水平;患者接受了CAG (cytarabine,aclarubicin,G-CSF) 化疗.
SDF-1α水平与临床因素,缓解状态和整体存活时间的相关性.

主要成果:

老年AML患者的血清SDF-1α水平明显高于对照组 (p < 0.001).
较高的SDF-1α预测化学疗法反应较差,总生存时间较短,独立于其他预后因素.
血清SDF-1α水平在完全响应者中下降,但在化学疗法后不响应者中保持不变.

结论:

血清SDF-1α升高与老年AML的不良化疗反应和生存有关.
基线血清SDF-1α水平显示,它有可能作为基于CAG的化疗结果的预后生物标志物.

关键词:

在CXC化学因子受体4型 (CXCR4) 中.急性髓性白血病 (AML) 是一种疾病.化疗反应的化学疗法反应.年长的老人老年人老年人.树皮细胞衍生的1α因子 (SDF-1α)

更多相关视频

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

相关概念视频

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...