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Updated: May 30, 2025

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Published on: October 21, 2022

宫癌中circRNA表达的预后和诊断价值:一个元分析

Yi Xu^1,2, Changxia Li^1,2, Lifang Cheng¹

¹Dermatology Hospital of Jiangxi Province, Jiangxi Provincial Clinical Research Center For Skin Diseases, Candidate Branch of National Clinical Research Center for Skin Diseases, Dermatology Institute of Jiangxi Province, The Affiliated Dermatology Hospital of Nanchang University, Nanchang, China.

Frontiers in oncology

|January 28, 2025

概括

循环RNAs (circRNAs) 显示出作为宫癌 (CC) 生物标志物的显著潜力. 这一元分析证实了它们在CC诊断,预后和与临床病理特征的相关性方面的作用,为患者管理提供了新的途径.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

子宫癌 (CC) 是一种普遍存在的生殖系统恶性瘤.
循环RNAs (circRNAs) 正在成为各种癌症的关键调节者.
在CC中circRNAs的诊断和预后潜力需要系统的评估.

研究的目的:

综合评估circRNAs作为宫癌潜在生物标志物的作用.
评估CC中circRNAs的诊断准确性,临床病理相关性和预后价值.
通过元分析综合现有研究的证据.

主要方法:

在主要的科学数据库 (PubMed,Cochrane Library,Web of Science,Embase,CNKI) 进行了系统的文献搜索,截至2024年5月3日.
数据提取集中在circRNA表达,诊断指标 (灵敏度,特异性,AUC),临床病理相关性 (ORs) 和预后意义 (HRs) 上.
对27项符合条件的研究进行了元分析.

主要成果:

分析包括27项涵盖诊断 (n=3),临床病理 (n=15) 和预后 (n=23) 方面的研究.
瘤性circRNAs的升高与不良的临床指标相关 (例如瘤大小,FIGO阶段,淋巴结转移) 并预测了更差的生存率 (HR=2.13).
下调的瘤抑制器circRNAs也与不良的临床参数和预后相关 (HR=2.20). 综合的诊断性能显示出高准确度 (AUC=0.91,灵敏度=0.85,特异性=0.83).

结论:

循环RNAs显示出作为诊断子宫癌的可靠生物标志物的巨大潜力.
循环RNA表达水平与CC的各种临床病理特征有显著的相关性.
循环RNAs作为有价值的预后指标,预测宫癌患者的生存结果.

关键词:

宫癌:宫癌是一种癌症.圆形的RNAs是圆形的RNAs.临床病理学临床病理学诊断诊断诊断诊断诊断诊断这是一个元分析.预后预后预后

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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...