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富图金康复配方缓解呼吸道炎症,粘液分泌和免疫功能障碍由SARS-CoV-2尖端蛋白诱导

Bo-Han Wang¹, Ke-Yao Yu², Xiao-Na Zhang³

¹NanJing JiangNing Hospital of Chinese Medicine/Affiliated jiangning Hospital of Chinese Medicine, China Pharmaceutical University, Nanjing, Jiangsu, 210029, People's Republic of China.

Journal of inflammation research

|January 28, 2025

概括

在SARS-CoV-2小鼠模型中,Fu Tu Sheng Jin康复公式 (FTSJRF) 降低了呼吸道炎症和粘液. 它还通过促进树突细胞成熟和T细胞平衡来帮助恢复免疫平衡.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
呼吸系统医学呼吸系统医学

背景情况:

严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染导致严重的呼吸道炎症和粘液过分分泌.
了解传统配方的免疫调节作用对于开发新型治疗策略至关重要.

研究的目的:

在SARS-CoV-2尖端蛋白诱导的肺损伤的小鼠模型中研究Fu Tu Sheng Jin康复公式 (FTSJRF) 的治疗潜力.
评估FTSJRF对呼吸道炎症,粘液产生和免疫细胞概况的影响.

主要方法:

一种小鼠模型是使用SARS-CoV-2尖端蛋白的内给药来建立的.
小鼠接受了不同剂量的FTSJRF.RF治疗.
肺病理,炎症标志物 (IL-4,TNF-α,IL-33),粘素基因表达 (MUC1,MUC4) 和免疫细胞群 (T辅助细胞,树突细胞) 通过组织学染色,ELISA,RT-qPCR和流细胞计分析.

主要成果:

SARS-CoV-2尖端蛋白诱导了显著的肺炎和损伤,增加了粘液分泌和炎症性细胞因子的升高.
治疗FTSJRF证明了对炎症,粘液产生和肺损伤的剂量依赖性抑制作用.
FTSJRF通过促进树突细胞成熟和恢复Th17/Treg和Th1/Th2细胞比率的平衡来调节免疫反应.

结论:

FTSJRF有效地减轻与SARS-CoV-2尖端蛋白暴露相关的气道炎症和粘液过分分泌.
FTSJRF具有免疫调节特性,有助于恢复呼吸道中的免疫平衡.

关键词:

在 COVID-19 疫情中,富图金康复公式富图金康复公式在SARS-CoV-2病毒中,尖蛋白是最常见的.呼吸道炎症呼吸道炎症免疫功能障碍免疫功能障碍粘液分泌物粘液分泌物

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