在肌缩侧硬化症患者中评估上部肠道运动活动和肠道症状:一项观察性研究
Emanuela Ribichini1, Nadia Pallotta1, Danilo Badiali1
1Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Frontiers in neurology
|January 28, 2025
概括
肌缩侧面硬化症 (ALS) 患者表现出上胃肠道运动异常,包括上食道 (UES) 和延迟胃排空. 这些发现表明ALS中潜在的自主神经系统 (ANS) 功能障碍.
科学领域:
- 胃肠病学 胃肠病学
- 神经学 神经学
- 运动神经元疾病 运动神经元疾病
背景情况:
- 耳鼻喉功能障碍是已知的肌缩侧面硬化症 (ALS) 的并发症.
- 了解ALS上部胃肠道 (GI) 运动功能对于患者的治疗至关重要.
- 消化道症状的变化可能存在,这取决于疾病发作 (腹筋与脊柱) 和严重程度.
研究的目的:
- 为了评估ALS患者上部消化道运动活动.
- 为了将胃肠道运动功能与腹筋/脊柱发作和ALS严重程度相关联.
- 为了确定与ALS表型相关的特定的胃肠道症状.
主要方法:
- 招募了具有特定功能和呼吸道标准的ALS患者 (囊筋/脊柱发作).
- 使用纤维光学内镜评估吞 (FEES),食道测量和胃空化研究.
- 评估肌肉力量 (MRC尺度) 和罗马症状问卷,用于胃肠道疾病.
主要成果:
- 分析了13名ALS患者 (5人患有凸骨,8人患有脊柱发作).
- 在5名患者中,FEES揭示了显著的消化不良,不论发病类型如何.
- 上食道关节 (UES) 压力升高;在子组中观察到UES和延迟的胃排空.
- 运动异常与临床ALS特征或胃肠道症状之间没有直接相关性.
结论:
- 一部分ALS患者表现出UES和延迟的胃排空.
- 这些发现表明自主神经系统 (ANS) 功能障碍在ALS病理生理学中的潜在作用.
- 需要进一步的研究,以探索ALS中ANS功能障碍和肠胃问题的联系.
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