2006年至2019年糖尿病青少年怀孕中早产和高血压疾病
Estelle Everett1,2,3, Christina S Han4, Michael Richley5
1Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Pediatric diabetes
|January 28, 2025
概括
患有糖尿病的青少年怀孕,包括1型,2型和妊娠期糖尿病,显示出早产和高血压疾病的风险明显更高. 这些发现强调了需要有针对性的干预措施,以改善这一群体中母亲和婴儿健康结果.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 青少年怀孕代表了一个脆弱的人群,具有独特的健康考虑.
- 青少年中糖尿病的患病率正在增加,这引发了人们对妊娠并发症的担忧.
- 高血压疾病和早产是怀孕的重大风险,特别是在青少年母亲身上.
研究的目的:
- 评估糖尿病 (1型,2型和妊娠) 与青少年怀孕中早产风险之间的关联.
- 评估由糖尿病复杂的青少年怀孕中高血压疾病的风险.
- 在青少年中发现这些妊娠并发症的趋势和差异.
主要方法:
- 利用国家儿童住院患者数据库 (KID) 从2006年到2019年,分析了超过180万名青少年劳动和分娩入院.
- 采用国际疾病分类 (ICD) 代码来识别糖尿病病例和妊娠并发症.
- 应用加权后勤回归来确定高血压疾病和早产与糖尿病状况相关的调整几率比率.
主要成果:
- 与没有糖尿病的青少年相比,患有任何形式的糖尿病 (T1D,T2D,GDM) 的青少年患有高血压疾病和早产的患病率显著更高 (p <0.001).
- 调整后的模型显示,糖尿病青少年患高血压疾病的几率增加 (T1D的OR为4.32,T2D为4.18,GDM为1.99) 和早产 (T1D的OR为4.53,T2D为3.35,GDM为1.18).
- 根据种族/种族,保险状况和收入水平,观察到结果的差异.
结论:
- 青少年糖尿病的增加对不良妊娠结果造成了重大风险,包括早产和高血压疾病.
- 尽管青少年怀孕率有所下降,但高血压疾病的发生率有所上升,这强调了糖尿病的影响.
- 紧急实施有针对性的干预措施至关重要,以减轻风险,并确保患有糖尿病的孕妇青少年获得更健康的结果.
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