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静坐行为,体力活动和骨关节炎之间的关联:来自NHANES 2007-2020和孟德尔随机分析的结果

Jiangqin He¹, Cao Zhang², Lili Yang¹

¹Department of Nursing, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.

Frontiers in public health

|January 28, 2025

概括

久坐不动的行为 (SB) 增加了骨关节炎 (OA) 的风险,而体力活动 (PA) 提供了保护. 建议最大限度地减少SB和增加PA,以减少OA的发展和管理这种情况.

科学领域:

风湿病学和肌肉骨健康
流行病学和公共卫生.
遗传学和精准医学遗传学和精准医学

背景情况:

骨关节炎 (OA) 是一种广泛的退行性关节疾病,具有多因素的病因.
静止行为 (SB) 和体力活动 (PA) 在OA病变发生中的作用尚未完全阐明.
了解生活方式因素和OA风险之间的相互作用对于预防和管理至关重要.

研究的目的:

调查静坐行为 (SB),体力活动 (PA) 和骨关节炎 (OA) 风险之间的关联.
通过横截面和门德尔随机化 (MR) 分析,探索SB,PA和OA之间的潜在因果关系.

主要方法:

从国家健康和营养检查调查 (NHANES) 中对24,738名参与者的横截面分析.
后勤回归和非参数曲线适配以评估SB,PA和OA关联以及剂量反应关系.
门德尔随机化 (MR) 分析使用遗传变异作为SB和PA的仪器变量来推断因果关系.

主要成果:

骨关节炎的患病率为13.47%;患有骨关节炎的人报告SB高,PA低.
观察到PA和OA风险之间的U形关联;严重的SB减弱了PA的保护作用.
核磁共振分析表明,基因推断的SB增加了OA的可能性 (OR 1.20),而增加的PA降低了OA的风险 (OR 0.85).

结论:

SB和PA是OA发展的重要可修改的风险因素.
减少久坐时间和增加体力活动是OA预防的建议策略.
MR的发现支持了SB,PA和OA之间的因果关系,为治疗和康复方法提供了信息.

关键词:

门德尔的随机化尼汉斯 (NHANES) 是一个名人.骨关节炎是一种关节炎.身体活动身体活动一个久坐不动的行为.

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