慢性肝病患者急性损伤:一篇综述
Hilary A Elom1, Yassmin Hegazy2, Edgar V Lerma3
1Department of Medicine, University of Missouri School of Medicine, United States.
Indian journal of nephrology
|January 28, 2025
概括
急性损伤 (AKI) 是慢性肝病 (CLD) 的严重并发症. 早期识别和管理AKI对于改善患者的生存和结果至关重要,特别是在肝移植之前.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 急性损伤 (AKI) 是慢性肝病 (CLD) 患者的常见和严重并发症.
- 在这个患者群体中,AKI在全球范围内对高发病率和死亡率做出了重大贡献.
- 肝移植 (LT) 提供了有利的结果,但有效的早期AKI管理对于生存至关重要.
研究的目的:
- 在CLD的背景下审查AKI的流行病学,病理生理学,管理策略和预后.
- 巩固目前关于AKI在CLD中的知识,以告知临床实践和未来的研究.
主要方法:
- 使用主要的科学数据库 (PubMed,Medline,Google Scholar) 进行了广泛的文献搜索.
- 搜索的重点是确定详细介绍了在CLD患者中AKI的流行病学,负担,临床表现,预后和管理的研究.
主要成果:
- 在住院的CLD患者中,AKI的患病率差异很大.
- AKI的多因素病因包括先天性原因,急性管道损伤,败血症,肠道出血,细菌转位和肝综合征 (HRS).
- AKI增加了慢性病后的发病率,死亡率和慢性病风险;管理取决于病因,血管收缩剂 (例如,特利普林素) 对HRS-AKI有希望,LT作为最终治疗.
结论:
- AKI是CLD的关键并发症,需要及时识别和干预.
- 诊断和管理AKI,特别是HRS,具有挑战性,需要高度的怀疑指数.
- 对新型治疗方法的进一步研究对于改善CLD患者AKI的结果至关重要.
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