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在胎盘术语中,胎儿胆小组织的免疫景观

Brianna M Doratt¹, Heather E True^1,2, Suhas Sureshchandra^3,4

¹Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, United States.

Frontiers in immunology

|January 28, 2025

概括

胎盘中的免疫细胞转向母亲的起源,肥胖影响炎症反应和潜在的胎儿神经发育. 这项研究揭示了怀孕期间胎盘免疫力的关键适应.

科学领域:

免疫学免疫学免疫学
怀孕研究怀孕研究
胎儿的发育胎儿的发育

背景情况:

胎儿胆小的免疫微环境包括霍夫尔细胞 (HBC) 和母体单细胞/巨细胞 (PAMM).
虽然第一季度的胎盘免疫力具有特征,但胎盘免疫细胞多样性和功能仍未得到充分探索.

研究的目的:

为了全面地表型化和功能性地表征长期的胆小性免疫细胞.
研究妊娠年龄和怀孕前肥胖对胎盘免疫细胞数量和功能的影响.
探索这些发现对胎儿神经发育的影响.

主要方法:

使用流式细胞计量,单细胞RNA测序 (scRNA-seq),CITE-seq和snATAC-seq.使用长期胆毛病免疫细胞的深度表型.
按怀孕前的BMI分层分析,以评估母亲肥胖的影响.
使用微质细胞进行体外建模,以调查肥胖对胎儿神经发育的影响.

主要成果:

孕期胎盘显示胎儿的HBCs减少,与第一季度相比,母亲的PAMMs增加.
孕产妇的巨细胞 (PAMM1b) 和HBC在孕期表现出显著的细胞能力.
怀孕期间的肥胖与炎症性基因表达的增加和小性髓状细胞中抗菌素基因表达的抑制有关.
肥胖症还导致微质激活标记的增加,并在体外模型中降低了细胞能力.

结论:

妊娠年龄和母亲的孕前肥胖症诱导胎儿胆小的显著免疫适应.
孕期肥胖可能会导致不良的妊娠结果,并可能通过微质功能障碍影响胎儿的神经发育.

关键词:

在表观基因组学上,表观基因组学.巨细胞是一个巨细胞.微质细胞中的微质细胞一个单细胞单细胞.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖胎盘胎盘胎盘胎盘怀孕怀孕怀孕怀孕怀孕翻译学翻译学翻译学

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