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相关概念视频

Liver Regeneration01:24

Liver Regeneration

3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

13.4K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.4K

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The entropic view of aging: from thermodynamics to biology.

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TRIM22-mediated ubiquitin-dependent degradation of FLT3-ITD overcomes TKI resistance in acute myeloid leukemia.

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相关实验视频

Updated: May 30, 2025

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology
12:36

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

15.5K

使用单细胞技术解码肝纤维化.

Tingting Zhou1, Musunuru Kiran2, Kathy O Lui3

  • 1CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Life medicine
|January 28, 2025
PubMed
概括
此摘要是机器生成的。

单细胞RNA测序正在通过揭示肝纤维化细胞和分子细节来彻底改变肝纤维化研究. 这项技术揭示了肝细胞的关键变化,为新的纤维化疗法铺平了道路.

关键词:
纤维化的利基.与脂质相关的巨细胞 (LAM)非对基细胞的细胞.恒星上的星区域划分区分区分区分区分区分区分区分区分区分区分区分区分区

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Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination
08:52

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination

Published on: February 18, 2017

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Cell Type-specific Gene Expression Profiling in the Mouse Liver
10:06

Cell Type-specific Gene Expression Profiling in the Mouse Liver

Published on: September 17, 2019

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相关实验视频

Last Updated: May 30, 2025

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology
12:36

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

15.5K
Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination
08:52

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination

Published on: February 18, 2017

11.0K
Cell Type-specific Gene Expression Profiling in the Mouse Liver
10:06

Cell Type-specific Gene Expression Profiling in the Mouse Liver

Published on: September 17, 2019

7.6K

科学领域:

  • 肝病学和免疫学 肝病学和免疫学
  • 分子生物学和遗传学 分子生物学和遗传学

背景情况:

  • 肝纤维化是一个复杂的过程驱动慢性肝病,缺乏有效的治疗方法.
  • 尽管进行了广泛的研究,但目前对肝纤维化机制的理解仍然不完整.

研究的目的:

  • 审查单细胞RNA测序 (scRNA-seq) 如何促进对肝脏纤维生成的理解.
  • 突出scRNA-seq在细胞亚群中的发现,分子事件和与肝纤维化相关的细胞相互作用.

主要方法:

  • 关于肝纤维化的最近单细胞RNA测序研究的综述.
  • 分析scRNA-seq数据,描述肝细胞,肝脏内皮细胞,肌纤维细胞和巨细胞的特征.

主要成果:

  • scRNA-seq提供了高分辨率的洞察力,了解肝脏纤维化过程中的细胞变化.
  • 发现包括新的疾病相关的细胞亚群和分子事件.
  • 已经阐明了影响纤维化进展的关键细胞相互作用.

结论:

  • scRNA-seq正在改变肝脏纤维化研究.
  • 了解这些病理生理变化对于开发有效的纤维化治疗至关重要.